No Kidneying Around! A Night with KRUK

40 years ago in the Medellin countryside, Columbia, a paediatrician noticed some of the children who came to him with kidney infection could not smile or form normal facial expressions. He named this disease urofacial syndrome. Having worked on this syndrome for nearly a decade our group of researchers in Manchester have discovered why the children's bladders were dysfunctional. These findings have had profound implications for people affected by the disease and the field of regenerative medicine. Although we are beginning to uncover a previously unknown biology much is still to be discovered.