© Pint of Science, 2020. All rights reserved.
When thing go wrong in the human body, they can really go wrong. We join a team of cutting edge researchers to explore the effects and treatments of chronic conditions. We also delve into the world of diabetes and it's causes.
To B or not to B: Cell identity in Type 2 Diabetes
Nicola Jeffery (Post Doctoral Researcher)
T2D affects over 415 million people globally where insulin resistance results in chronically high blood sugar. Beta cells in our pancreas are the cells that release insulin and it is these cells which help us to control blood sugar but in T2D the number of beta cells declines over time. It was thought that this was because the cells were dying but new studies are showing that the cells are actually changing into other cell types. This talks explains how unhealthy lifestyles contribute to T2D and how they may be causing our beta cells to change their identity.
Exploring fluctuating symptoms in chronic conditions: the patient's perspective
Antoinette Davey (Research Associate)
Individuals with chronic conditions regularly experience fluctuations in their symptoms at different times of day and year (seasonal effects). However, these fluctuations are rarely taken into account when collecting patient reported outcome measurements. Patient reported outcome measurements are used by clinicians and researchers to monitor the progression of a condition and to test if intervention has been effective. The results pose questions about the use of outcome measurements such as when they should be administered and how often to get accurate readings of what patients are experience.
Over the course of its 120-day lifetime, a red blood cell will travel 400km throughout your microcirculatory system. It will effortlessly pass through wide blood vessels and squeeze through narrow ones, in order to deliver oxygen to all the tissues in your body. How do our red cells sense when more oxygen is required? In diseases like diabetes, where this vital delivery mechanism is impaired, what has gone wrong? This talk explores the cells of you circulatory system in an interdisciplinary approach; fast becoming the norm in research within the medical field.