Other Exeter events

Exeter Postdoc Appreciation Week - Thu Seminar

This venue is fully accessible. Please note this event is for staff and students at the university.
Past event - 2021
23 Sep 16:00 to 17:30
Henderson Lecture Theatre, University of Exeter Business School, Xfi building,
Exeter EX4 4ST
As part of National Postdoc Appreciation Week (#NPAW2021) we are running two afternoons of seminars, with talks from Neuroscience Postdocs and PhD researchers. Come along to learn about topics within circadian biology, neuroimmunology, epigenetics and neural networks.

This is Thursday's seminar, click at bottom of page for Friday's seminar. Refreshments and food will be provided. All research staff, students and postdocs welcome! Places are limited so book now. Please register one ticket per person.

TikTok: Exploring the circadian clock in sympathetic preganglionic neurons

Dr Christian Nathan (Post-doctoral Research Associate)
The day-night cycle governs our physiology, within the brain lies the control centre, the suprachiasmatic nucleus (SCN). The SCN is thought to communication with peripheral clocks throughout the body to regulate diurnal rhythmicity. One such peripheral clock could exist within sympathetic preganglionic neurons (SPNs) which are the final point of influence the central nervous system has on sympathetic nerve activity. Our findings suggest that SPNs contain circadian clock machinery which may control expression of genes/proteins that influence SPN and sympathetic nerve activity.

The effects of GLP-1R activation on neuronal activity

Type 2 diabetes mellitus (T2DM) and neurodegenerative disease such as Alzheimer’s disease share common pathophysiological characteristics such as insulin resistance and decreased glucose metabolism. GLP-1 receptor agonists are used as treatments for patients with T2DM, however some of these drugs also have beneficial effects in the brain. Here, we use GLP-1 receptor activation to study the effects of such drugs on neuronal activity. Our works will provide a basis for future works to study whether the effects of GLP-1R activation on neuronal activity is a result of direct or modulatory mechanism, and also how the regulation of neural circuits by this receptor system guides behaviour.

Circadian timekeeping in the brainstem satiety centre under well-balanced and high-fat diets

Dr Lukasz Chrobok (Honorary Research Fellow)
Historically, it was believed that the master clock in the suprachiasmatic nucleus of the hypothalamus controls all daily rhythms in physiology and behaviour. Here, we present novel findings on the existence of the autonomous circadian timekeeping centre in the brainstem dorsal vagal complex (DVC) of mice and rats. We further characterise its physiological relevance and disturbance under high-fat diet, what is reflected in blunted daily rhythms of food intake. Our findings have clear implications for future chronotherapy of obesity.

Other Henderson Lecture Theatre events

University of Exeter Business School, Xfi building, Exeter, EX4 4ST, United Kingdom University of Exeter Business School, Xfi building, Exeter, EX4 4ST, United Kingdom