Other London events

“Micro”-climate Change

Step-free access is available. There will also be access to a private bar where food and drinks will be available for purchase.
Past event - 2019
21 May Doors 7pm
Event 7.30-9.30pm
The Griff Inn Bar & Kitchen, BLSA Building, Stepney Way, Whitechapel,
London E1 2AT
Communication is key in most aspects of life: cells are no different. The environment in which a cell lives is crucial for it to function properly – so what happens when this environment is altered? Join us to explore the significance of this question in the context of both cancer, with Prof. Balkwill’s talk on tumour microenvironment; and new drug targets for disease treatments with Dr. Whiteford!

Pint of Science goodies to be won during the night!

Dethroning the king

Every cancer is a complex microenvironment of malignant cells supported by a wide variety of ‘normal’ cells that are recruited and often corrupted’ by the malignant cells to help the cancer grow and spread. There are ‘exhausted’ immune cells, over-active fibroblasts and tortuous leaky blood vessels often supported by a stiff and abnormal fibrous mesh. Understanding and ‘reprogramming’ this microenvironment can restrict vital supplies to the cancer and re-awaken the immune cells to recognise and destroy malignant cells.

Targeting disease ‘off switches’

Cells respond to each other and their environment via the action of cell-surface molecules called receptors. Cells have many receptors and each one recognises different molecules (ligands). When a ligand engages with a receptor a signal is generated inside the cell which alters the cell’s behaviour. These interactions help in our growth and development, the way we fight infection and the way in which we heal ourselves. We are trying to exploit a family of receptors which we believe are disease ‘off switches’.