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For a long time, animals have been used as a part of biomedical research to answer basic questions about human bodies, and on the path to discovering new treatments for diseases. For over half a century, national and international legislation has included the principle of the 3Rs (Replacement, Reduction and Refinement) in the regulations surrounding the use of animals in research. The 3Rs involves many different ways to reduce animal use in research, and this event explores some of these methods for such wide-ranging fields as neurodegenerative diseases and treatments for type 1 diabetes.
Mind the Gap: using touchscreen computing to facilitate translational neuroscience research
Translating research from laboratory models to therapeutics for neurodegenerative or psychiatric illness is difficult. Touchscreen computing has harmonised cognitive assessment in models and patients to close the ‘translational gap’. Here I describe how touchscreens can be used to evaluate motivation and emotional state and the benefits for patient wellbeing, model system welfare and study design.
New approaches to solve the riddle of Type 1 diabetes
Type 1 diabetes is caused by immune mediated destruction of the insulin producing beta cells in the pancreas, leaving the body unable to take up glucose. I am interested in processes that destroy the beta cells in type 1 diabetes. Through studying the mechanism of action of drugs, we can learn not just how to better treat the disease, but also which cells and processes are of crucial importance in disease progression. I will describe the novel observations about type 1 diabetes we have made using a non-invasive imaging technique.