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Thanks to the kind support of Pint of Science and Proteintech, we'd like to invite you to celebrate postdocs and their science!
Join us for some FREE food and refreshments to hear about WIMM postdoc research, in an informal and friendly environment.
Goodie bags are available on a first-come first-served basis, so sign-up and get in early! And don't forget to have a chat with your local Proteintech rep to learn all about their reagents and pipelines.
Join us for some FREE food and refreshments to hear about WIMM postdoc research, in an informal and friendly environment.
Goodie bags are available on a first-come first-served basis, so sign-up and get in early! And don't forget to have a chat with your local Proteintech rep to learn all about their reagents and pipelines.
Targeting the alternative lengthening of telomeres pathway
Telomeres are the protective ends of chromosomes. After every cell division, telomeres shorten due to the end-replication problem. This continues until they reach a critically shortened state where they elicit DNA damage checkpoint activation, stopping further divisions. Therefore, for cancer cells to divide indefinitely, they must maintain the ends of their chromosomes through a telomere maintenance mechanism to prevent replicative senescence or apoptosis.
In about 90% of cancers, the enzyme telomerase, which replenishes telomeric DNA, is reactivated, permitting indefinite cell divisions. As many as yet untreatable childhood cancers extend their telomeres via and Alternative Lengthening of Telomeres (ALT) pathway, a greater understanding of this pathway may provide much needed treatments for such cancers.
We're looking into this by using commercially available cell lines along with a number of molecular biology and proteomics techniques, including co-immunoprecipitations, microscopy and iPOND as well as numerous ALT-specific assays.
In about 90% of cancers, the enzyme telomerase, which replenishes telomeric DNA, is reactivated, permitting indefinite cell divisions. As many as yet untreatable childhood cancers extend their telomeres via and Alternative Lengthening of Telomeres (ALT) pathway, a greater understanding of this pathway may provide much needed treatments for such cancers.
We're looking into this by using commercially available cell lines along with a number of molecular biology and proteomics techniques, including co-immunoprecipitations, microscopy and iPOND as well as numerous ALT-specific assays.
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